What are Long COVID and ME/CFS, and how may Low-Dose Aripiprazole help?
Long COVID and ME/CFS can cause persistent fatigue, brain fog, unrefreshing sleep and post-exertional malaise. Low-dose aripiprazole is being explored as an off-label treatment for these symptoms. [1]
A Stanford study of 101 ME/CFS patients found that 74% experienced improvement in at least one symptom after taking low-dose aripiprazole [2]
Among patients who responded, fatigue, brain fog and unrefreshing sleep improved, while the average frequency of post-exertional malaise episodes was reduced by half [3]
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🔬 LDN Use Cases
Crohn's Disease
Studies have shown LDN to reduce Crohn’s disease activity in 88% of patients, while 33% achieved remission after 12 weeks
Rheumatoid Arthritis
RA is most often associated with chronic inflammation, while LDN has been shown to lower chronic inflammation
Fibromyalgia
LDN acts on specific pain receptors to reduce their over-sensitivity while stimulating the body to naturally lower inflammation
Thyroid Dysfunction
LDN has been shown to
alleviate some or all of symptoms of hypo- & hyperthyroidism & regulate the way the thyroid works
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Evidence-based treatments for long COVID
Low-dose naltrexone to calm the overactive immune system.
Coenzyme Q10 to recharge the mitochondria.
Patients who do not mind using a safe, compounded alternative.
Low dose optimized for safety and anti-inflammatory effects, supported by over 40 years of evidence treating viral infections and autoimmune disease.
Key Benefits
Boost Energy / Reduce PEM
LDA reduces persistent fatigue and post-exertional malaise, supporting better energy and everyday functioning.
LDA may improve unrefreshing sleep, helping you feel more rested during the day.
Better Sleep
LDA may reduce brain fog and support better focus, memory and mental clarity.
Clearer Thinking
Milder Crashes
LDA may reduce the severity and duration of symptom crashes following physical or mental activity.
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Frequently Asked Questions (FAQs)
Low-dose aripiprazole may be well tolerated, but side effects can include headache, insomnia, restlessness, agitation and irritability. Treatment should only begin after a clinical assessment.
Your doctor may start treatment at a very low dose and adjust it gradually. Do not change your dose or stop treatment without speaking to the medical team.
LDA may not be suitable for people with an aripiprazole allergy or certain medical conditions. Pregnancy, breastfeeding, current medication and medical history must be discussed with the doctor.
LDA is being explored for fatigue, brain fog, unrefreshing sleep and post-exertional malaise associated with ME/CFS and similar Long COVID symptoms. Results vary, and improvement is not guaranteed.
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